We unexpectedly discovered that several cationic antimicrobial peptides can undergo phase separation with components of the bacterial cytoplasm, hereby killing the cells. Our results suggest that this mechanism—named polycation poisoning—is widespread across the tree of life, the mode of action of several venom peptides, and implicated in a range of age-related neurodegenerative diseases.

Additionally, we recently set up a translational project where we are trying to target pathogen condensates as new antiviral and antibiotic strategies. We are currently focusing on viral diseases of high unmet need.